“Superman's Enemy Lois Lane”
When Superman finally confronts Lois about their crumbling marriage, she responds with a super-powered fistfight, which makes Superman realize he isn't dealing with Lois at all, but with the Parasite.
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Superman #157 (1987) is issue #157 of DC's Superman (1987–2006), with a cover date of June 2000. Written by Jeph Loeb and drawn by Ed McGuinness.
Credits, characters and story details from the Grand Comics Database, CC BY-SA 4.0.