“Swamp Spirit”
In the "remote bayous of southern Louisiana" they tamper with a serum for human longevity, accidentally releasing an evil spirit. When the spirit goes for the girl, it gets destroyed.
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Spook #30 (1953) is issue #30 of Star Publications [1949-1954]'s Spook (1953–1954), with a cover date of October 1954. Written by Jay Disbrow and drawn by Jay Disbrow, Iger Shop and George Peltz.
Credits, characters and story details from the Grand Comics Database, CC BY-SA 4.0.